Wednesday, 22 January 2020 | 05:38 WIB

NIPT Examination Can Detect Chromosomal Abnormalities

Dr Manggala Pasca Wardhana, SpOG (netralnews)

JAKARTA, NETRALNEWS.COM - Dr. Manggala Pasca Wardhana, SpOG, says the medical world has been progressing, both in terms of equipment and ability to examine. Some of the updates in the obstetrics field, especially Fetomaternal (or Mother and Baby), are the Non Invasive Prenatal Test (NIPT) technique.
NIPT has begun to be known by the public, especially couples of childbearing age and pregnant women. Dr. Manggala said a good and complete understanding of this examination is very necessary to find out the needs and decide to carry out this examination.
"In recent decades, the concern for various diseases caused by genetic problems is increasing, so efforts to find safe and effective examination techniques in the fetus in the womb continue to develop," he said to Netralnews.
He continued that the fetus is the center of attention because it was considered a patient or individual who continued to grow and develop in the womb. So that efforts to find out fetal problems since the womb continue to be developed to get the best outcome at the time of labor later.
Manggala continued that in 1997, Dennis Lo found that a cell fragment in the placenta (placenta) attached to the mother's womb could be found and captured in the mother's blood.
It was also explained that the placenta is a product of pregnancy so that genetic material or DNA in the cell can present fetal DNA, so this is known as cell free fetal DNA.
"Now with high technology, these cells can be captured through the mother's blood and carried out an examination to see if there are genetic problems in these cells," he stressed.
According to Dr. Manggala, a new examination can be carried out over 10 weeks waiting for the cell to be large enough to be able to be adequately captured by the sophisticated inspection equipment.
So what are the abnormalities that can be detected? The main disorder that can be examined using this technique is the number of chromosomes (or aneuploidy). Chromosomes are DNA strands that contain important messages for human formation and development.
It was explained that the chromosomes numbered 23 pairs (46 pieces) with 1 pair in the form of a Sex chromosome that determines male or female. Abnormalities in the number of chromosomes that may be sufficient are trisomy 21 (Down syndrome), trisomy 18 (Edward syndrome), trisomy 13 (Patau syndome).
"The greatness of this examination technique is that it has a very high detection ability, up to 98 percent, higher than the other techniques for examining previous chromosomal abnormalities," he explained.